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  • Editor in Chief: Prof. Giovanni Gambaro
  • Co-Editor: Benedetta Bussolati
  • Current issue: Vol. 26 issue Suppl. 22 , 2013 (November-December)

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Vol. 24 - Issue 2 (March-April 2011)

Marked improvement by high-dose chemotherapy and autologous stem cell transplantation in a case of light chain deposition disease

Marked improvement by high-dose chemotherapy and autologous stem cell transplantation in a case of light chain deposition disease

J Nephrol 2011; 24(2): 246 - 249

Article Type: CASE REPORT

DOI:10.5301/JN.2011.6241

Authors

Keiichi Matsuzaki, Isao Ohsawa, Tomohito Nishitani, Yukihiko Takeda, Hiroyuki Inoshita, Masaya Ishii, Miyuki Takagi, Satoshi Horikoshi, Yasuhiko Tomino

Abstract

A 55-year-old woman presented with heavy proteinuria (6.2 g/day) in April 2007. Because monoclonal IgG-? was detected in serum and urine samples, bone marrow aspiration and renal biopsy were performed. She was diagnosed with plasma cell dyscrasia because a bone marrow aspiration specimen showed plasma cells at 6.1%. Renal tissues revealed the formation of nodular glomerulosclerosis which was negative for Congo-red staining. Renal immunohistochemistry showed positive staining for kappa light chains in the nodular lesions, proximal tubules and part of Bowman’s capsules. Her renal involvement was diagnosed as light chain deposition disease. Proteinuria disappeared and renal function stabilized after high-dose chemotherapy and autologous stem cell transplantation. It appears that an early initiation of active therapy such as high-dose chemotherapy and autologous stem cell transplantation may be beneficial for patients with light chain deposition disease.

Article History

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Authors

  • Matsuzaki, Keiichi [PubMed] [Google Scholar]
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo - Japan
  • Ohsawa, Isao [PubMed] [Google Scholar]
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo - Japan
  • Nishitani, Tomohito [PubMed] [Google Scholar]
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo - Japan
  • Takeda, Yukihiko [PubMed] [Google Scholar]
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo - Japan
  • Inoshita, Hiroyuki [PubMed] [Google Scholar]
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo - Japan
  • Ishii, Masaya [PubMed] [Google Scholar]
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo - Japan
  • Takagi, Miyuki [PubMed] [Google Scholar]
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo - Japan
  • Horikoshi, Satoshi [PubMed] [Google Scholar]
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo - Japan
  • Tomino, Yasuhiko [PubMed] [Google Scholar]
    Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo - Japan

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