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  • Editor in Chief: Prof. Giovanni Gambaro
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  • Current issue: Vol. 26 issue Suppl. 22 , 2013 (November-December)

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Vol. 25 - Suppl. 19 - Renal Ageing

Pharmacogenetics in older people: what we know and what we need to know

Pharmacogenetics in older people: what we know and what we need to know

J Nephrol 2012; 25(Suppl. 19): 38 - 47

Article Type: SUPPLEMENT - ORIGINAL ARTICLE

DOI:10.5301/jn.5000137

Authors

Davide Seripa, Giulia Paroni, Maria Urbano, Stefano A. Santini, Grazia D’Onofrio, Alberto Pilotto

Abstract

The prevalence of therapeutic failures (TFs) and adverse drug reactions (ADRs) markedly increased in older subjects. However, both TFs and ADRs did not always appear related to the presence of multiple pharmacologic treatments, a common status in subjects aged 65 and over. Instead, they seem more related to variations in the genes encoding protein metabolizing and transporting drugs. Thus, variations in these proteins may account for the inter-individual differences observed in drug efficacy, including the most severe clinical consequences TFs and ADRs. The genetics of drug metabolizing enzymes (DMEs) and drug transporters (DTs) is a very active area of multidisciplinary research, overlapping the fields of medicine, biology, pharmacology, and genetics. These proteins are virtually responsible for metabolism and disposition, and thus the efficacy, of a number of drugs currently used in clinical practice. This article explored some basic concepts of the pharmacogenetics of DMEs and DTs. We also focused current knowledge of the genetic basis of TFs and ADRs of the most common drugs currently used in geriatric clinics. The knowledge of what we know and what we need to know is needed to advance the application of pharmacogenetics in clinical practice, in order to introduce personalized treatments for elderly people.

Article History

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Authors

  • Seripa, Davide [PubMed] [Google Scholar]
    Gerontology and Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia - Italy
  • Paroni, Giulia [PubMed] [Google Scholar]
    Gerontology and Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia - Italy
  • Urbano, Maria [PubMed] [Google Scholar]
    Gerontology and Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia - Italy
  • Santini, Stefano A. [PubMed] [Google Scholar]
    Laboratory of Clinical Chemistry, Department of Clinical Pathology, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia - Italy
  • D’Onofrio, Grazia [PubMed] [Google Scholar]
    Gerontology and Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia - Italy
  • Pilotto, Alberto [PubMed] [Google Scholar]
    Gerontology and Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia - Italy; and Geriatrics Unit, Azienda ULSS16 Padova, S. Antonio Hospital, Padova - Italy

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